The vascular and lymphatic systems form distinct networks throughout the body, each serving independent functions. Blood vessels primarily transport oxygen from the lungs to peripheral tissues, while lymphatic vessels collect interstitial fluid not fully recovered by capillaries and return it to the bloodstream via the venous angle. However, lymphatic endothelial cells originate from venous endothelial cells during embryogenesis, and both systems share many signaling molecules.

Moreover, comparing venules and collecting lymphatic vessels reveals that their histological features are difficult to distinguish without immunostaining for marker molecules. This raises the question of how these two systems differentiate from each other and maintain their independence—an area with many unresolved aspects. In this lecture, we will discuss recent findings from our laboratory, including the role of the tumor suppressor gene Flcn as a “gatekeeper molecule.” Flcn suppresses the expression of Prox1, a master transcription factor for lymphatic endothelial differentiation, in venous endothelial cells, thereby regulating the plasticity between venous and lymphatic endothelial cells. Additionally, we will present evidence that tip cells of vascular endothelial cells during development exhibit high plasticity toward lymphatic endothelial differentiation.

These fundamental studies are expected to contribute to advancements in understanding and treating conditions such as lymphedema and advanced cancer in the future.

President Isao Koshima (Professor in the Department of Plastic and Reconstructive Surgery at Hiroshima University Hospital) of this research society will present the latest findings and global trends related to the invited lecture. The session will include a surgical video demonstration highlighting key techniques.

After the lecture, there will be a lively online panel discussion with the speakers.
We hope you will join us for this informative event!

Panelist

• – Prof.Isao Koshima M.D., Ph.D.
• – Prof.Yoshiaki Kubota M.D., Ph.D.
• – Dr. Chavre Sachin M.D., Ph.D. Consultant, Plastic and Microvascular Reconstruction Surgeon, Department of the Plastic and Reconstructive Surgery, Thangam Hospital from INDIA
• – Dr. Jung-Ju Huang, Taiwan M.D., Ph.D.(Scheduled) Chief, Breast reconstruction Center, Associte professor,Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Linkou, from Taiwan
• – -Dr. Fouad Alomari (Scheduled) Consultant, Department of Maxillofacial Surgery and Diagnostic Sciences, King Faisal Medical City, SAUDI ARABIA

We hope you will join us for this informative event!

Speakers :

Sponsorship Opportunities:

To continue hosting our regular lecture series, we warmly welcome your support and sponsorship. If you are interested, please do not hesitate to reach out. We are currently seeking event sponsors and offer the following benefits: 

• ・Your company logo and name will be displayed on our research association’s website as well as the application site (Conference Park), ensuring recognition among all participants and site visitors.
• ・A direct link to your company’s website will be included on the Sponsors and Advertisers page.
• ・Your company name will be introduced by the event host during the sponsor introduction segment.
• ・Your logo and company/organization name will be prominently featured in the opening and closing videos, visible to all participants.
• ・A 15-second commercial will be included in the opening and closing videos.

 

If you are interested in sponsoring our online lecture series, “Future of Surgery” and “Surgeon Talk,” organized by our research association, please contact us at info@ikou-funding.com.